JIN Lab

RNA Biology · Bioinformatics

Research · Platform · Publications

聚焦 RNA 生物学与生物信息学研究,整合实验室常用在线工具、研究简介与近年学术成果。

个人简介

博士,教授。浙江理工大学“521”中青年拔尖人才,“创新嘉兴 精英引领计划”创业领军人才, 浙江省生物化学与分子生物学学会理事。主要从事 RNA 生物学相关的研究, 在 RNA 纳米的设计及其抗病作用方面取得良好的成果。主持或参与完成国家级项目 8 项、 省部级项目 10 多项。在国内外发表学术论文 40 余篇,其中 SCI 收录 30 余篇。 授权国家发明专利 10 多项。

研究领域

主要从事生物信息学方面的工作,重点关注各类 RNA 的识别及功能研究领域。

Bioinformatics Tools

生物信息学工具

01

RNAnano_Designer

An RNA nano-designer for designing lssRNA targeting specific genes and self-assembly folding to RNA nanostructures of triangle, square, pentagon, hexagon and tetrahedron.

//bi.sky.zstu.edu.cn/ssFRND/
02

dsRNA_designer

An effective and specific dsRNA designer for pest RNA interference with off-target analysis against human, bees and other environmental organisms.

https://bi.sky.zstu.edu.cn/dsRNA_design/
03

siRNA_Designer

An effective and specific siRNA designer for pest RNA interference with off-target analysis against human, bees and other environmental organisms.

https://bi.sky.zstu.edu.cn/siRNA_designer/design.html
04

Codon_optimizer

Optimize the codon preference of the target gene in Escherichia coli based on the codon usage frequency of the source species.

https://bi.sky.zstu.edu.cn/code_optimized/
05

WJ-RNA_Designer

An RNA nano-designer for designing lssRNA targeting specific genes and self-assembly folding to 3WJ- and 4WJ-RNA nanostructures.

https://bi.sky.zstu.edu.cn/Rnano/index.html
06

TCM_detector

A species detector for traditional Chinese medicine based on DNA fingerprinting.

https://bi.sky.zstu.edu.cn/TCM_detector/index.php
07

MYCOsiRNA

An effective and specific siRNA designer for fungi and oomycete RNAi based on the assessments of target site accessibility and genome-wide off-target selection.

https://bi.sky.zstu.edu.cn/MYCOsiRNA/index.html
08

Batch Primer3 Designer

Batch PCR primer design for multi-FASTA sequences with editable Primer3 constraints, supporting per-sequence primer output and downloadable result tables.

https://bi.sky.zstu.edu.cn/primer3_batch/
09

RNAi BioReport

Registration-oriented bioinformatics report generation for RNAi pesticides with multi-FASTA parsing, dsRNA window recommendation, siRNA pre-screening, and downloadable structured report files.

https://bi.sky.zstu.edu.cn/bio_report/

SCI Publications

近三年发表 SCI 学术论文情况

  1. Sun S, Yan L, Liu Z, Jin W*. Design of Anti-Tumor RNA Nanoparticles and Their Inhibitory Effect on Hep3B Liver Cancer. Biomolecules. 2026; 16(1):45.
  2. Lu M, Jiang W, Liu Z, Liu Y, Wu F, Jin W*. Development of a Dual Gene-Targeted Multi-Sirna with Branched Structure and Its Role in the Therapy of Liver Cancer. Pharmaceuticals. 2025; 18(12):1844.
  3. Ya Chen, Yiqing Liu, Yani Huang, Fangli Wu, Weibo Jin*. Development of triangle RNA nanostructure for enhancing RNAi-mediated control of Botrytis cinerea through Spray-Induced Gene Silencing without extra nanocarrier. Biology-basal. 2025-11-13
  4. Jin WB, Zhang XY, Wu FL*, Zhang PW. Selection of BcTRE1 as an effective RNAi target for dsRNA-Based control of Botrytis cinerea. Physiological and Molecular Plant Pathology. 2025; 139:102773.
  5. Huang H, Liu X, Liu Y, Wu F, Jin W*. Genome-Wide Identification and Expression Analysis of 1-Aminocyclopropane-1-Carboxylate Synthase (ACS) Gene Family in Myrica rubra. International Journal of Molecular Sciences. 2025; 26(10):4580. https://doi.org/10.3390/ijms26104580
  6. Zhao, X., Liu, Y., Huang, H., Sun, Y., Wu, F., & Jin, W*. (2024). A Simple and Efficient One-Step Synthesis System for Flexible Production of Circular RNA in E. coli. Biomolecules, 14(11), 1416. https://doi.org/10.3390/biom14111416
  7. Zhao, X., Liu, Z., Liu, Y., Lu, M., Xu, J., Wu, F., & Jin, W*. Development and application of an RNA nanostructure to induce transient RNAi in difficult transgenic plants. Biotechnology Journal, 2024, 19:e2400024.
  8. Wu F, Yan L, Zhao X, Lv C, Jin W*. Development of an RNA Nanostructure for Effective Botrytis cinerea Control through Spray-Induced Gene Silencing without an Extra Nanocarrier. Journal of Fungi. 2024; 10(7):483.
  9. Sun J, Lu S, Xiao J, Xu N, Li Y, Xu J, Deng M, Xuanyuan H, Zhang Y, Wu F, Jin W*, Liu K*. Inhibition of SARS-CoV-2 Replication by Self-Assembled siRNA Nanoparticles Targeting Multiple Highly Conserved Viral Sequences. Viruses. 2024; 16(7):1072.
  10. Guo K, Huang Z, Wang C, Liu X, Chen Y, Fang J, Jin W, Xu J, Wu F*, Zhou X*. Nematicidal effects of silencing arginine kinase in the pine wood nematode, Bursaphelenchus xylophilus, determined using a dsRNA-like siRNA assembly. Int J Biol Macromol. 2024; 279:135401.
  11. Wu F, Huang Y, Jiang W and Jin W* (2023) Genome-wide identification and validation of tomato-encoded sRNA as the cross-species antifungal factors targeting the virulence genes of Botrytis cinerea. Front. Plant Sci. 14:1072181.